The United States of America, As Represented by the Secretary, Department of Health and Human Services

Nigel H Grieg

Harold W Holloway

Edward J Goetzl

Qian-Sheng Yu

David Tweedie

Weiming Luo

A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R-Rare each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.

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Phoenix, MD, United States of America

Nigel H Grieg