Evolva Sa

Danmarks Tekniske Universitet

University of Copenhagen

Niels Bjerg Jensen

Michael Naesby

Birger Lindberg Møller

Johan Andersen-Ranberg

Eirini Pateraki

Björn Hamberger

Beata Joanna Lehka

Michael Eichenberger

Ernesto Simón Vecilla

Walden Emil Bjørn-Yoshimoto

Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.

Biosynthesis of phenylpropanoids and phenylpropanoid derivatives

The invention relates to recombinant microorganisms and methods for producing manoyl oxide.

Methods and materials for biosynthesis of manoyl oxide

The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

Biosynthesis of forskolin and related compounds

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Kastrup, Denmark

Niels Bjerg Jensen