Roche Palo Alto LLC

Hoffmann-La Roche Inc.

Other

F. Hoffmann-La Roche Ag

Nidhi Arora

Tobias Gabriel

David Michael Goldstein

Nolan James Dewdney

Michael Soth

Roland Joseph Billedeau

Teresa Alejandra Trejo-Martin

Matthew C Lucas

Counde O'Yang

Francisco Xavier Talamas

Sharada Shenvi Labadie

Shaoqing Chen

Johannes Cornelius Hermann

Clara Jeou Jen Lin

Andreas Kuglstatter

Amy Geraldine Moore

Jutta Wanner

Yansheng Zhai

Eva Papp

Kristen Lynn McCaleb

Compounds of the formula I or II: wherein X, m, Ar, Rand Rare as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators

Compounds of formula Ia or Ib: wherein A, W, X, Y, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.

Substituted pyrazolo[3,4-d]pyrimidines as p38 MAP kinase inhibitors

Compounds effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.

Substituted pyrazolo{3,4-D}pyrimidines as p38 map kinase inhibitors

Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof,wherein m, k, B, R, Rand Rare those defined herein, and compositions comprising the same. Also provided are methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.

Indazole derivatives and methods for using the same

Compounds of the formula I: where A, B, X, Y, Z, k, R, Rand Rare those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.

Substituted pyrazolo [3,4-d] pyrimidines and methods of using the same

Compounds of the formula Ia or Ib: wherein A, B, X, Y, Z, W, k, R, R, R, Rand Rare those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a subject.

Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same

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Cupertino, CA, United States of America

Nidhi Arora