Zoetis Services LLC

Nicole Rae Gibson

Hsien-Jue Chu

Zhichang Xu

Wumin Li

Provided are immunogenic and vaccine compositions and methods for their preparation and use, which compositions are effective in protecting against, minimizing the severity of, preventing, and/or amelioratinginfection. Administration to an animal of one or two doses of an adjuvanted live avirulentcomposition disclosed herein is effective in providing immunity to the animal and protection from infection with a virulent strain ofthereby reducing the severity of and/or preventing disease caused by one or more virulent strain of. Also provided are compositions, which further comprise one or more antigen such as, for example, one or more live bacteria, bacterin, toxoid, and/or virus and/or viral antigen. Exemplified are immunogenic compositions, comprising an adjuvanted live avirulentand compositions, comprising Porcine Circovirus Type 1-Type 2 chimera modified live vaccine (cPCV1-2) in further combination with an adjuvanted live avirulent

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Humboldt, IA, United States of America

Nicole Rae Gibson