The University of Manchester

City of Hope

University of Dundee

National and Kapodistrian University of Athens

Nicole Pouli

Nikolaos Lougiakis

Paul Townsend

Panayiotis Marakos

Nikolaos Kastrinakis

Panagiotis Marakos

Vassilis Gorgoulis

David A Horne

Sangkil Nam

Alexios-Leandros Skaltsounis

Ravi Salgia

Konstantinos Evangelou

Ilias Christos Tzortzatos

Vassilis G Gorgoulis

Athanassios Kotsinas

Russell Petty

A compound, or a salt or solvate thereof, according to formula I as defined herein and pharmaceutical composition comprising said compound. Compounds of formula I are capable of detecting senescence. As such, these compounds are useful in methods of detecting or imaging senescent cells or extracts thereof or senescence in a subject or a biological sample taken from a subject.

Imaging compounds for detecting or imaging senescent cells

Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.

Pyridopyrazine compounds and uses thereof

The present disclosure relates to compounds of the formula (1) that function as senescent cell detectors: wherein the SBB analogues refer to de novo synthesized derivatives with structural similarity to the Sudan Black B dye, L is an appropriate chemical bond and hapten is biotin, or digoxigenin, or 2,4-dinitrophenol, or fluorescein, but more preferably biotin. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. 

Compounds, linked with haptens, for the detection of senescent cells

The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R, R, R, Rand Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB). 

Compounds for the detection of senescent cells

Growing community of inventors

Athens, Greece

Nicole Pouli