The Johns Hopkins University

Rutgers, the State University of New Jersey

Nicole M Parrish

Craig Arthur Townsend

Gary R Pasternack

Francis P Kuhajda

James D Dick

Gyanu Lamichhane

Joel S Freundlich

Sean Ekins

Evan P Lloyd

Amit Kaushik

Pankaj Kumar

Shaogang Li

Craig A Townsend

New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among &#x3b2;-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.

Inhibitors of bacterial growth

This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R&#x2014;SO-Z-CO&#x2014;Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is &#x2014;CH&#x2014;, &#x2014;CHCH&#x2014;, &#x2014;NH&#x2014;NH&#x2014;, &#x2014;O&#x2014;, &#x2014;&#x2014;NH&#x2014;, &#x2014;O&#x2014;NH&#x2014;, &#x2014;CH&#x2014;NH&#x2014;, &#x2014;CH&#x2014;O&#x2014;, &#x2014;NH&#x2014;O&#x2014;, &#x2014;NH&#x2014;CH&#x2014;, &#x2014;O&#x2014;CH&#x2014;, and &#x2014;CH&#x2550;CH&#x2014;; Y is &#x2014;NH, &#x2014;O&#x2014;CH&#x2014;CH, &#x2014;CO&#x2014;CO&#x2014;O&#x2014;CH, and &#x2014;O&#x2014;CH; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as, drug resistant, and pathogenicsp.

Antimicrobial compounds

This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R&mdash;SO &mdash;Z&mdash;CO&mdash;Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from &mdash;CH &mdash;, &mdash;O&mdash;, and &mdash;NH&mdash;, two of these radicals coupled together, or &mdash;CH &boxH;CH &mdash;; Y is &mdash;NH , O&mdash;CH &mdash;C H , &mdash;CO&mdash;CO&mdash;O&mdash;CH , or O&mdash;CH ; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize &agr;-substitued, &bgr;-hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as drug-resistant and

Growing community of inventors

Ellicott City, MD, United States of America

Nicole M Parrish