Alderbio Holdings LLC

H. Lundbeck A/s

Nicole M Janson

John A Latham

Leon F Garcia-Martinez

Patricia Dianne McNeill

Benjamin H Dutzar

Brian Robert Kovacevich

Jens J Billgren

Danielle Mitchell

Maria-Cristina Loomis

Katie Olson Anderson

Patricia Dianne Mcneill

Katie Olson

Gary Lesnicki

Leon F Garcia-martinez

Pei Qi

Gary L Lesnicki

Danielle M Mitchell

Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as

High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as

The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.

Anti-CGRP compositions and use thereof

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Seattle, WA, United States of America

Nicole M Janson