Wake Forest University

Nicole Hope Levi

David Loren Carroll

Louis Charles Argenta

William D Wagner

Michael J Morykwas

Jie Jerry Liu

Stephen Tatter

Christopher Michael MacNeill

James Eric Jordan

Lawrence Xavier Webb

Thomas L Smith

Rui Wang

John H Stewart, Iv

Tabitha Rosenbalm

Elizabeth Graham

Faith M Coldren

Elizabeth Grace Gurysh

Brian Werner

J Baxter Mcguirt

Manoj Namboothiry

Christopher Michael Macneill

Elizabeth Grace Graham

The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.

Devices and methods for treating spinal cord tissue

The present invention relates to nanoparticle compositions and, in particular, to composite polymeric nanoparticle compositions. A composite nanoparticle described herein comprises a photoluminescent polymeric component and a photo-thermal polymeric component. The photoluminescent polymeric component and the photo-thermal polymeric component can each comprise a single polymeric species or multiple polymeric species.

Composite polydots and applications thereof

Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.

Nanofiber-based graft for heart valve replacement and methods of using the same

A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.

Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage

A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.

Conduit for peripheral nerve replacement

In one aspect, electrically conductive conjugated polymeric compositions are described herein demonstrating compatibility with aqueous solvents and/or phases. The ability to provide aqueous compatible compositions from previously water insoluble conjugated polymeric systems, in some embodiments, can facilitate use of such systems in a variety of aqueous applications, including biological applications.

Low band gap conjugated polymeric compositions and applications thereof

The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.

Small-scale pressure sensors

The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.

Device and method for treating central nervous system pathology

The present invention relates to compositions and methods for treating cancer and, in particular, to composition and methods comprising nanostructures. In one embodiment, the present invention provides a composition comprising a mixture, the mixture comprising at least one nanoparticle and at least one chemotherapeutic.

Growing community of inventors

Winston-Salem, NC, United States of America

Nicole Hope Levi