Ciba Specialty Chemicals Corporation

Basf Se Corporation

Basf Se Ludwigshafen

Nicole End

Martin Studer

Gabriele Baisch

Reinhold Öhrlein

Stephan Burkhardt

Reinhard Sommerlade

Yvonne Richter

Beate Fröhling

Barbara Wagner

Menno Hazenkamp

Ulrich Berens

Kai-Uwe Schöning

Sophie Marquais-Bienewald

Marie-Josée Dubs

Hauke Rohwer

Pier Giorgio Cozzi

Catherine Stoessel

A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding &#x3b1;-hydroxyketone or &#x3b1;-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The &#x3b1;-hydroxyketones and &#x3b1;-aminoketones thus obtainable are useful inter alia as photoinitiators.

Preparation of alpha-hydroxyketones

A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding &#x3b1;-hydroxyketone or &#x3b1;-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The &#x3b1;-hydroxyketones and &#x3b1;-aminoketones thus obtainable are useful inter alga as photoinitiators.

Preparation of &#x3b1;-hydroxy and &#x3b1;-amino ketones

The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or &#x2014;N(CH)OCH, Ris a hydroxy-protecting group and Ris a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.

Process for the preparation of intermediates useful in the synthesis of statin derivatives

The present invention relates to the use of metal complex compounds having hydrazide ligands as oxidation catalysts. Further aspects of the invention are formulations comprising such metal complex compounds, novel metal complex compounds and novel ligands. The metal complex compounds are used especially for enhancing the action of peroxides, for example in the treatment of textile material, without at the same time causing any appreciable damage to fibers and dyeings. There is also no appreciable damage to fibers and dyeings if these metal complexes are used in combination with an enzyme or a mixture of enzymes.

Use of metal complex compounds as oxidation catalysts

Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof

The present invention concerns coloring keratin fibers, especially human hair, with colored metal complexes.

Coloring keratin fibers with metal complexes

The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH)OCH, Ris a hydroxy-protecting group, and Ris a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation. 

Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof

The invention relates to novel ligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of formula I and mixtures of such compounds, wherein

Isoxazoline derivatives as P N ligands

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Oberwil, Switzerland

Nicole End