Warner-lambert Company

Nicole Chantel Barvian

William Chester Patt

David T Connor

Patrick Michael O'Brien

Drago R Sliskovic

Michael William Wilson

Daniel Fred Ortwine

Richard Dennis Dyer

Adam Richard Johnson

Joseph Armand Picard

Kimberly Suzanne Para

Kevon Ray Shuler

Melean Visnick

Christine Nylund Kolz

Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein:

Isophthalic acid derivatives as matrix metalloproteinase inhibitors

The present invention provides compounds of Formula I wherein W, Q, E, D, R, R, R, Y, K, R, R, R, G, and the double bond denoted '*' have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

Benzoxazin-3-ones and derivatives thereof as therapeutic agents

Selective MMP-13 inhibitors are pyridine derivatives of the formulaor a pharmaceutically acceptable salt thereof,wherein:

Pyridine matrix metalloproteinase inhibitors

Selective MMP-13 inhibitors are isophthalic acid derivatives of the formulawherein:

Selective MMP-13 inhibitors are pyrimidine derivatives of the formulaor a pharmaceutically acceptable salt thereof,

Pyrimidine matrix metalloproteinase inhibitors

The present invention provides compounds of formula (I) wherein R, Z, Y, W, R, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to the inhibition of the enzyme 15-lipoxygenase. Thus, the compounds of formula (I) and their pharmaceutically acceptable salts are useful for treating diseases with an inflammatory component, including atherosclerosis, diseases involving chemotaxis of monocytes, inflammation, stroke, coronary artery disease, asthma, arthritis, colorectal cancer, and psoriasis.

1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase

Selective MMP-13 inhibitors are pyridine derivatives of the formulaor a pharmaceutically acceptable salt thereof,

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Ann Arbor, MI, United States of America

Nicole Chantel Barvian