Massachusetts Institute of Technology

Harvard College

The Brigham and Women's Hospital, Inc.

The Broad Institute, Inc.

Nicole C Joller

Aviv Regev

Vijay K Kuchroo

Hongkun Park

Alexander K Shalek

Ana Carrizosa Anderson

Jellert Gaublomme

Nir Yosef

Chuan Wu

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

T cell balance gene expression, compositions of matters and methods of use thereof

Growing community of inventors

Brookline, MA, United States of America

Nicole C Joller