Delalande S.a.

Delande S.a.

Nicole A Dorme

Claude P Fauran

Guy M Raynaud

Thierry F Imbert

Guy R Bourgery

Michel Langlois

Michel J Turin

Jeannine A Eberle

Alain J Renaud

Enantiomer of absolute configuration S of formula: ##STR1## where: X=O or S; and

Enantiomers of absolute configuration S of amide derivatives of

New derivatives of 3-amino quinuclidine of formula: ##STR1## in which X=sulfur or oxygen; R=H, lower alkyl or benzyl; and Ar=substituted phenyl or substituted pyrimidinyl. These new derivatives have utility in therapeutics as accelerators of the gastro-intestinal motor function and as medicament potentiators.

3-amino quinuclidine derivatives and the application thereof as

Compounds of the formula ##STR1## where Ar is phenyl, substituted phenyl, .alpha.-furyl or .alpha.-thienyl, and

1-(2'-Aroyl eth-1'yl) 2-(4'-acetamido piperazine-1'yl methyl)

New 1-(2'-aroyl eth-1' yl) 2-(4'-acetamido piperazine-1' yl methyl)

Compounds of the formula ##STR1## wherein R is alkyl of 1-4 carbon atoms, phenyl, or phenyl substituted by one or more halogen or trifluoromethyl, and Z is ##STR2## wherein R.sub.1 is hydrogen, alkyl of 1-4C, 2,2-dimethyldioxolan-4-yl methyl, or 2,3-dihydroxy prop-1-yl, R.sub.2 is ##STR3## wherein ##STR4## is morpholino, pyrrolidino, piperidino or hexamethyleneimino, and n is an integer from 4 to 7. The compounds are prepared by reacting R-substituted 4-chloro-2-methyl furo (2,3d) pyrimidine with HZ. The compounds possess antiulcerous, antibronchoconstrictive and anticholinergic, analgesic, antihistamine, diuretic, cardiovascular analeptic, antiinflammatory and hypertensive properties.

Furo (2,3d) pyrimidines

Compounds of the formula ##STR1## in which Ar is .alpha.-furyl or .alpha.-thienyl and pharmacologically acceptable salts thereof are provided as novel therapeutic agents which have inter alia utility in treating asthma, respiratory deficiency, visceral spasms, gastroduodenal ulcers or hyperchlorhydria.

1-[2'-(.alpha.-Furoyl or .alpha.-thienoyl)eth-1'-yl]-2-(4'-cinnamyl

Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R.sub.1 and R.sub.2 each is alkyl having one to 4 carbons or ##EQU2## is piperidino, pyrrolidino, morpholino and hexamethyleneimino. The compounds are prepared by reacting the corresponding 2-chloromethyl benzimidazole with ##EQU3## The compounds possess analgesic, antihypertensive, gastric antisecretory, antiinflammatory, antibronchoconstrictive, anticholinergic, spasmolytic, sedative, antiulcerous, vasodilatatory, central nervous system stimulant, antiarythmic, diuretic and antihistaminic properties.

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Nicole A Dorme