Commissariat a L'energie Atomique

Serono Genetics Institute S.a.

Université Des Sciences Et Technologies De Lille

Nicolas Sarrut

Yves Fouillet

Raymond Charles

Patricia Claustre

Gilles Marchand

Guillaume Delapierre

Hubert Jeanson

Jean Dijon

Florence Ricoul

Jean-Frederic Clerc

Claude Vauchier

Christine Peponnet

Antoine Gruss

An active method for decanting the dispersed phase in the continuous phase of an emulsion. According to the method, repulsive forces created by an electric field are used on the drops constituting the dispersed phase. The electric field scans the reservoir containing the emulsion, enabling the dispersed phase to be concentrated in a determined region of the reservoir, for the recovery and/or analysis of the emulsion. A device implements the method.

Microdevice and method for separating an emulsion

A microfluidic system including: a substrate, one surface of which is covered with electrodes configured to move, under effect of an electric field, microdrops of a liquid phase including at least one functionalized ionic liquid; and capillaries for introducing a liquid extraction fluid onto the surface and for extracting the liquid extraction fluid from an orifice by forced convection, to obtain an extraction bath located on the surface for extraction of at least one chemical or biological compound from the liquid phase, and the bath is open to a surrounding space on at least two of its opposite sides, for moving, in contact with the surface, the microdrop upstream and downstream of the bath.

Method for extracting at least one compound from a liquid phase comprising a functionalized ionic liquid, and microfluidic system for implementing said method

A microfluidic component comprises at least one channel () delineated by a top wall () and a bottom wall () and two opposite side walls (). The distance (P) between the top wall () and the bottom wall () of the channel () is greater than or equal to 25 micrometers and first and second sets of nanotubes () are respectively borne by the two opposite side walls () for the component to present a particularly high ratio between the contact surface and the available volume and a limited overall surface size. In addition, the distance between the two opposite side walls () is about a few micrometers and preferably comprised between 3 and 5 micrometers.

Microfluidic component with a channel filled with nanotubes and method for its production

A method of transferring mass of at least one solute between a liquid first phase and a fluid second phase that is immiscible with the first phase, the method comprising moving at least one droplet of said liquid first phase in a microfluidic device by using electric-type forces (electrowetting or dielectrophoresis) within a space that is filled with said fluid second phase. Said droplet is preferably moved by said electric-type forces along a path between a point for injecting said droplet into said microfluidic device, and an extraction and/or analysis zone, said path being defined in such a manner that said droplet sweeps through a significant fraction of said space filled with said fluid second phase. The method may include a step of transferring said droplet using said electric-type forces to a chemical analysis device integrated in said microfluidic device, and a step of chemically analyzing said droplet. The invention also provides a device for implementing such a method.

Microfluidic method and device for transferring mass between two immiscible phases

A method for extracting at least one chemical or biological compound from a liquid phase including at least one functionalized ionic liquid, via a liquid extracting fluid that is miscible with the ionic liquid, and a microfluidic system implementing the method. The extraction method includes moving, on one surface of a microfluidic system, at least one microdrop of the liquid phase into an extraction solution that includes the extracting fluid and that is localized on the surface to obtain in output of the solution, under effect of an electric field, an extract moving away from the surface that is rich in extracting fluid and enriched in the at least one compound, and a raffinate moving on the surface that is rich in ionic liquid and deleted in the at least one compound.

The microfluidic device comprises at least one microchannel bounded by a bottom wall, side walls and a top wall and which is designed to contain at least one liquid and at least one fluid non-miscible with the liquid. The microfluidic device comprises means for stabilizing the interface between the liquid and the fluid. The means for stabilizing comprise at least one electrode arranged on at least one part of a first wall of the microchannel, over the entire length thereof, and at least one counter-electrode arranged over the entire length of the microchannel, on at least one part of a second wall, arranged facing the electrode. The electrode and counter-electrode are preferably respectively arranged on the bottom and top wall of the microchannel.

Microfluidic device wherein the liquid/fluid interface is stabilized

A microfluidic device including a microfluidic chip assembled to an electrospray structure. The microfluidic chip includes at least one microfluidic channel leading through an outlet aperture to a surface area of the microfluidic chip. The electrospray structure includes at least one thin, planar point provided with a capillary slot that terminates at the end of the point so as to form an aperture for ejection of a liquid to be sprayed. The electrospray structure is arranged on the surface area of the microfluidic chip so that the point is cantilivered with respect to the microfluidic chip and so that the outlet aperture of the microfluidic device leads to the capillary slot of the point, which microfluidic device also has a mechanism to apply an electrospray voltage to the liquid to be sprayed.

Microfluidic device comprising an electrospray nose

The invention concerns the performing, in continuous flow, of a biological, chemical or biochemical protocol on substances to be analysed, comprising several steps which consists in: in causing a mobile analysis support () comprising means () for receiving substances to be analysed and reagents to move past; implementing the steps of the protocol on the substances as the mobile analysis support () moves past.

Method and system for performing in continuous flow a biological, chemical or biochemical protocol

The invention relates to a device () for distribution of at least one liquid product, the device comprising at least one injection tube () supplied by a liquid product and being provided with an outlet orifice () capable of cooperating with an inlet orifice () of a reception tube () for reception of each liquid product. According to the invention, the outlet orifice () of each injection tube () and the inlet orifice () of the reception tube () open up into a sealed reservoir () full of an immiscible liquid (), the outlet orifice () of each injection tube () being at a spacing from the inlet orifice () of the reception tube () and able to be located close to the reception tube (), the device () also comprising means () for pressurizing the immiscible liquid ().

Liquid product distribution device and method

The invention relates to a microfluidic device for injecting series of mobile reaction chambers () having non-miscible segmenters () in micro-channels (to), comprising:

Device for parallel and synchronous injection for sequential injection of different reagents

Devices and methods for carrying out a chemical or biochemical protocol are disclosed. In one embodiment, the chemical or biochemical protocol is performed by cycling at least one thermal transfer member between at least two temperatures while liquid samples on which the chemical or biochemical protocol is to be performed are continuously moving through at least one temperature regulated zone upon which the at least one thermal transfer member acts. In some embodiments, the device comprises a sample transport member that comprises liquid samples in sample receiving regions. The sample transport member moves the samples continuously through a temperature regulated zone which cycles between at least two temperatures while the liquid samples are moving through a temperature regulated zone on which at least one thermal transfer member acts. In some embodiments, the sample receiving regions comprise wells, hydrophillic films or hydrophillic filaments.

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Seyssinet, France

Nicolas Sarrut