Rhodia Chimie

Shasun Pharma Solutions Limited

Nicolas Roques

Bernard Langlois

Laurent Saint-Jalmes

Claude Wakselman

Marc Tordeux

James Russel

Thierry Vidal

Gerard Forat

G&eacute;rard Forat

Sylvie Large

James Russell

The invention relates to a method for preparing a fluorinated and silylated derivative having a bond between the bearing carbon of at least one fluorine and one silicon. This method comprises at least one step during which a derivative of formula (I) Rf&#x2014;CO&#x2014;O-D, in which D is selected among silylated radicals, is placed in the presence of a base. The inventive method is used for synthesizing fluorinated derivatives.

Reagent and method for preparing a fluorinated and silylated derivative

The invention concerns a method for functionalizing a double bond and, more particularly, a double bond bearing a metalloid atom. Said functionalization is produced by the action of perhalogenated sulphonyl chloride on the carbon bearing sulphur in the presence of a free radical initiator, preferably by homolytic cleavage. The invention is useful in organic synthesis.

Process for functionalizing a double bond

A reagent comprising a compound of formula (I): R &mdash;M(X)(Z) &mdash;Y&mdash;R, wherein R is a hydrocarbon radical advantageously having at most 10 carbon atoms and being selected from alkyls and aryls; R is a radical of formula II: R &mdash;(C&Xgr; ) &mdash;CF &mdash;, where R is a fluorine or chlorine atom or a carbon radical, m is 0 or a integer from 0-12, and each &Xgr;, which may be the same or different, is a chlorine or preferably fluorine atom, with the proviso that when m is 0, R is electroattractive, preferably a fluorine atom; n is 0 or 1; M is a non-metal selected from carbon and chalcogens with an atomic number than oxygen; and each of X, Y and Z, which are the same or different, is a chalcogen; as well as a generator, for consecutive or simultaneous addition. The reagent is useful for organic synthesis.

Reactant, compound and process for the perfluoroalkylation of a nucleophile, and the derivatives obtained

The subject-matter of the present invention is a process of use in perfluoroalkylation and a reactant for making use of this process. This process is defined in that it comprises a stage in which a material of formula RfH and a base (or a species capable of generating a base) are brought into contact, in a polar and anhydrous medium, with a substrate carrying at least one electrophilic functional group. Application to organic synthesis.

Process of use in perfluoroalkyation and reactant for making use of this process

The invention concerns a reagent and a family of compounds. The reagent contains by successive or simultaneous addition: a material of formula RfH, a silicophilic base, a trivalent nitrogenous derivative containing no hydrogen and at least two silyl groups. The invention is useful for organic synthesis.

Compounds useful for perhalogenoalkylation, reagent for implementing these compounds and synthesis method for obtaining these compounds

Reactant, compound and process for the perfluoroalkylation of the

Perfluoroalkylation method and reagent therefor

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Lyons, France

Nicolas Roques