Janssen Pharmaceuticals, Inc.

Ac Immune Sa

Nicolas Piot

Andreas Muhs

Maria Pihlgren Bosch

Marija Vukicevic Verhille

Donata De Marco

Elizabeth Anne Ramsburg

Charlotte Sadaka

Saroj Raj Ghimire

Jaap Goudsmit

Andrea M Pfeifer

David T Hickman

Chakkumkal Anish

Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

Method of safe administration of phosphorylated Tau peptide vaccine

Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Compositions of phosphorylated tau peptides and uses thereof

Method of safe administration of phosphorylated tau peptide vaccine

Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.

Heterologous administration of tau vaccines

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Grandvaux, Switzerland

Nicolas Piot