Mutabilis

Nicolas Lecointe

Francis Chevreuil

Sophie Chasset

Julien Barbion

Christophe Simon

Frédéric Le Strat

Julie Brias

Audrey Caravano

Fabien Faivre

Sébastien Richard

Sophie Vomscheid

Benoît Ledoussal

Chrystelle Oliveira

Géraldine Le Fralliec

Vincent Gerusz

Benoit Ledoussal

Rémi Lebel

Dmytro Atamanyuk

Sophie Briet

Frédéric Le-Strat

Benôit Ledoussal

Laurence Farescour

Sophia Briet

The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a &#x3b2;-lactamase inhibitor. 

Heterocyclic compounds and their use in preventing or treating bacterial infections

The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam compounds, for the prevention or treatment of bacterial infections. The present invention also relates to the use of these compounds as &#x3b2;-lactamase inhibitors and/or as antibacterial agents.

A compound of formula (I) or a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.

The invention relates to the compounds (I) and their acids and bases salts: wherein: Formula (I) the dotted line indicates a double bond; X is N or C&#x2014;Rand Y is N or C&#x2014;R, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is selected from the group of substituents as defined in the application, or B is a 4 or (6-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, linked by a carbon atom, and possibly substituted as defined in the application; Ris Hydrogen or a substituent as defined in the application; Ris Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them. 

Heteroaromatic derivatives and their use as pharmaceuticals

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Paris, France

Nicolas Lecointe