Pharmacor Inc.

Taimed Biologics, Inc.

Taimed Biologies, Inc.

Nicolas Leberre

Brent Richard Stranix

Jean-Francois Lavallee

Valérie Perron

Guy Milot

Dominik Herbart

Chandra Panchal

Val&eacute;rie Perron

Jean-Fran&ccedil;ois Lavall&eacute;e

Chandra J Panchal

Jean-François Lavallee

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein Rmay be, for example, 2-pyridyl-CH&#x2014;, 3-pyridyl-CH&#x2014;, 4-pyridyl-CH&#x2014;, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R&#x2014;CO)&#x2014;, Rbeing selected from the group consisting of piperonyl, 2-pyranzinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONRR, CHOH or CHOR.

Protease inhibitors

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein Rmay be, for example, 2-pyridyl-CH&#x2014;, 3 -pyridyl-CH&#x2014;, 4-pyridyl-CH&#x2014;, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R&#x2014;CO&#x2014;, Rbeing selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONRR, CHOH or CHOR.

Aromatic derivatives as HIV aspartyl protease inhibitors

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Montreal, Canada

Nicolas Leberre