Centre National De La Recherche Scientifique

Universitè De Montpellier

Ecole Nationale Superieure De Chimie De Montpellier

Association Pour La Recherche Et Le Developpement Des Methodes Et Processus Industriels

Ecole Des Mines D'ales

Centre National De La Recherche Scientifique-cnrs

Nicolas Le Moigne

Jean Martinez

Frédéric Lamaty

Benjamin Gallard

Yves Yeboue

Thomas-Xavier Metro

A continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I): Ra-POLYPEP-Rc (I) wherein: POLYPEP is a poly-amino acid compound, Ra and Rc are as specified, the method including the steps of: a) feeding an extrusion reactor with (1) a compound of formula (II) Ra-PEPNt-Rg (II) wherein; PEPNt is a mono- or a poly-amino acid compound, Ra and Rg are as specified, and (2) a compound of formula (III) H-PEPCt-Rc (III) wherein: PEPCt is a mono- or a poly-amino acid compound, and Rc is as defined in the absence of any solvent, so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and b) collecting the compound of formula (I) from the extrusion reactor.

Continuous, solvent-free and non-enzymatic peptide synthesis by reactive extrusion

Growing community of inventors

Saint Sebastien d'Aigrefeuille, France

Nicolas Le Moigne