Ge Healthcare Limited

Ge Healthcare As

Nicolas Lasbistes

Bengt Langstrom

Anthony Eamon Storey

Farhad Karimi

Steven Michael Fairway

Alexander Mark Gibson

Lorenzo Williams

Robert James Nairne

Clare Louise Jones

Denis Raymond Christophe Bouvet

Mikkel Jacob Thaning

Oskar Axelsson

Duncan George Wynn

Robert James Domett Nairne

Duncan Wynn

The invention relates to a process for preparation of a compound of formula (I): Ris selected from Calkyl, Calkenyl, and Calkynyl;which comprises:(i) reaction with fluoride, suitably [F]fluoride, of a corresponding compound of formula (II): wherein Ris selected from hydrogen, Calkyl, Chaloalkyl, Caryl, Carylalkyl, &#x2014;(CHCHO)&#x2014;CHwherein q is an integer of from 1 to 10;Ris as defined for the compound of formula (I); andRis a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

Fluorination process

The invention relates to a process for preparation of a compound of formula (I): Ris selected from Calkyl, Calkenyl, and Calkynyl; which comprises: (i) reaction with fluoride, suitably [F]fluoride, of a corresponding compound of formula (II): wherein Ris selected from hydrogen, Calkyl, Chaloalkyl, Caryl, Carylalkyl, &#x2014;(CHCHO)&#x2014;CHwherein q is an integer of from 1 to 10; Ris as defined for the compound of formula (I); and Ris a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed. 

Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.

Contrast agents

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Surrey, United Kingdom

Nicolas Lasbistes