Adir Et Compagnie

Les Laboratoires Servier

Nicolas Guilbaud

Alain Pierre

Ghanem Atassi

Patrick Casara

Claude Guillonneau

Thierry Le Diguarher

Yves Charton

Gordon Tucker

Gilbert Dorey

Michael Burbridge

David Billington

Jean-Louis Peglion

Jacqueline Bonnet

Jean-Paul Vilaine

John Hickman

Emile R Bisagni

Laurence Kraus-Berthier

Massimo Sabatini

Isabelle Picard

Ghanem Aasssi

Pascale Leon

Anne Marie Chollet

Cycloheptene compounds

The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R , R , R , R represent a hydrogen or an alkyl group, or R and R together form a cycloalkyl group; R represents a hydrogen, an alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, hetereoalkylalkyl, hetereocycloalkyl, hetereocycloalkylalkyl group (all optionally substituted), or a &mdash;CO&mdash;R group; and R represents R or OR or NR R , with R representing an aryl, arylalkyl, heteroaryl or heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl group (all optionally substituted), and R representing an alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl (all optionally substituted); or R and R form with the nitrogen atom and the Z group bearing them a saturated monocyclic, bicyclic or tricyclic group, partially unsaturated or unsaturated, with 5 to 16 chain links containing 1 to 7 heteroatoms and optionally substituted; R represents a hydrogen atom or a hydroxy group, and in the latter case R , R , R , R are independently selected among hydrogen and alkyl; Z represents a hydroxy, alkoxy, alkenyloxy, benzyloxy group or a NH&mdash;OR group; X represents a sulphur, a SO, SO group (in those cases where R and R are different from an alkyl) or a group &mdash;CO&mdash;O&mdash; (in which case R and R form a cycloalkyl group), or X represents an oxygen atom; W represents a W &mdash;(A) or W &mdash;B&mdash;W &mdash;(A) group wherein W and W represent an aryl or heteroaryl group, A is a standard substituent of aromatic cycles, B a bond, an oxygen or an alkylene, alkenylene, alkynylene group, and p is an integer ranging between 0 and 5; T and T represent a bond or an alkylene, alkenylene, or alkynylene group. The invention is useful for preparing medicines.

Carboxylic and hydroxamic acid compounds inhibiting metalloproteases, method for preparing same and pharmaceutical compositions containing them

The compounds of formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and A are as defined in the description, their optical isomers and N-oxides, and pharmaceutically acceptable addition salts thereof with an acid or base, and the use thereof as anti-tumor agents.

Ellipticine compounds

Compounds of the formula: ##STR1## in which R.sub.1, R.sub.2, A and B are as defined in the description, their optical isomers, N-oxides and addition salts with a phar-maceutically acceptable acid, and their use as anti-tumor agents.

Bis-pyrido�4,3-b!carbazole compounds

Compounds of formula (I): ##STR1## wherein: R is selected from the radicals: ##STR2## Y is selected from ##STR3## R.sub.1 represents the radical ##STR4## and A, B, C, D, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description, and also the possible geometric isomers and/or diastereoisomers and/or enantiomers thereof in pure form or in the form of a mixture. The compounds of the present invention have a therapeutic use as a result of their angiogenesis-inhibiting activity.

Cyclohexane compounds

A compound selected from those of formula (I): ##STR1## in which: A either represents --OR.sub.6, and B represents --CH.sub.2 --X,

Tetrahydropyran compounds

The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to increase the sensitivity of tumor cells to antitumor agents. A compound disclosed is d-2-{[2-(2-(N-p-nitrobenzylamino)ethoxy)ethoxy]methyl}-4-(2,3-dichlorophen yl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine.

1,4-dihydropyridine compounds

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La Celle Saint Cloud, France

Nicolas Guilbaud