Innate Pharma

Orega Biotech

Centre Leon Berard

Orega Biotech Sas

Nicolas Gourdin

Laurent Gauthier

Carine Paturel

Ivan Perrot

Benjamin Rossi

Stéphanie Chanteux

Christophe Caux

Christine Menetrier-Caux

Angela Virone-Oddos

Marielle Chiron

Alessandro Masiero

Ingo Focken

Jochen Beninga

Alexandre Tang

Sambasiva Rao

Leila Sevigny

Yanfeng Zhou

Christine Menetrier-caux

The present invention relates to antigen-binding compounds that inhibit the enzymatic activity of soluble human CD39. The invention also relates to cells producing such compounds; methods of making such compounds, and antibodies, fragments, variants, and derivatives thereof; pharmaceutical compositions comprising the same; methods of using the compounds to diagnose, treat or prevent diseases, e.g., cancer.

Nucleic acids encoding and methods of producing proteins comprising antibody chains

The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with Fc-engineering

Compositions and methods for treating cancer

Antibodies that bind human CD39 and inhibit ATPase activity of a soluble extracellular domain human CD39 polypeptide

Provided are antibodies that bind and inhibit CD73, are capable of increasing the proliferation of T cells in the presence of CD39-expressing B cells and ATP. The invention also relates to cells producing such compounds; methods of making such compounds, and antibodies, fragments, variants, and derivatives thereof; pharmaceutical compositions comprising the same; methods of using the compounds to diagnose, treat or prevent cancer.

CD73 blocking agents

Growing community of inventors

Marseilles, France

Nicolas Gourdin