Almac Diagnostics Limited

Almac Diagnostic Services Limited

Almac Diagnostics Services Limited

Almac Diagonostics Limited

Nicolas Goffard

Richard Kennedy

Timothy Davison

Denis Paul Harkin

Laura A Hill

Katherine E Keating

Vitali Proutski

Fionnuala Patterson

Steve Deharo

Max Bylesjo

Jude O'Donnell

Steven Walker

Laura Taggart

Eileen Parkes

An immune response subtype of cancer is associated with DNA damage which allows subjects to be stratified for particular therapies including immune therapies which may be combined with DNA damage therapeutics. A method for predicting responsiveness to an antagonist of an inhibitory immune checkpoint and/or an agonist of a stimulatory immune checkpoint comprises determining the expression level of at least one gene selected from Table 2B, 2A or 1 in a sample from the subject. The determined expression level is used to predict responsiveness to an antagonist of an inhibitory immune checkpoint and/or an agonist of a stimulatory immune checkpoint.

Gene signature for immune therapies in cancer

Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Molecular diagnostic test for cancer

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Belfast, United Kingdom

Nicolas Goffard