Spexis Ag

Nicolas Desjonqueres

Daniel Obrecht

Anatol Luther

Glenn E Dale

Francesca Bernardini

Grégory Upert

Emile Brabet

Beta-hairpin peptidomimetics of the general formula (I), and pharmaceutically acceptable salts thereof, with P, X, Q., and optionally L being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such asand/orand/orand/orand/or. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

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Kembs, France

Nicolas Desjonqueres