Telik, Inc.

Nicolas Cairns

Steven R Schow

Louise Robinson

Prasad V V S V Manchem

Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of animals, especially humans, with hyperglycemia, especially for the treatment of type 2 diabetes. Processes for preparation of the compounds, and their use in assays, are also disclosed.

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Burlingame, CA, United States of America

Nicolas Cairns