Johnson Matthey Public Limited Company

Resolution Chemicals Limited

Johnson Matthey Inc.

Macfarlan Smith Limited

Nicolas Archer

Michael Bease

Barbara Jamieson

Saroop Matharu

Alan Kenneth Greenwood

Brian Heinrich

Ewart Grant

Maureen Young

Neil John Goodwin

Derek Mchattie

Robert S Marmor

Timothy Davies

Amy Price

Christopher Murray

David August

Saroop Singh Matharu

Brian W Heinrich

Hongzhi Zhang

Robert Marmor

Paul Young

An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.

Method of preparing buprenorphine

The present invention provides processes for preparing morphinan-6-one compounds, in particular oxymorphone and salts thereof, having improved impurity profiles.

Process for the preparation of morphinan-6-one compounds

The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40&#xb0; C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6&#x3b1;-oxymorphol produced is &#x2266;3.00 area % as determined by HPLC.

Process for the preparation of oxymorphone alkaloid and oxymorphone salts

The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6&#x3b1;-oxycodol in an amount &#x2266;about 0.800 area % as determined by HPLC.

Process

&#x394;9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The &#x394;9 THC acid is then converted to &#x394;9 THC which is further purified and combined with a carrier for pharmaceutical use.

Production of &#x394; 9 tetrahydrocannabinol

Growing community of inventors

Edinburgh, United Kingdom

Nicolas Archer