Institut National De La Sante Et De La Recherche Medicale

Université D'angers

L'universite D'angers

Nicolas Anton

Jean-Pierre Benoit

Patrick Saulnier

The invention relates to a composition comprising in an aqueous phase, particles having a diameter in the range of 20 to 500 nm, said particles containing:&#x2014;an oil phase;&#x2014;in said oil phase,&#x2014;an aqueous droplet, or&#x2014;a nanocapsule (NC) comprising:&#x2014;an aqueous core, and&#x2014;a polymeric shell or a shell composed of an amphiphilic substance; and&#x2014;a surfactant. This composition is particularly useful for encapsulating hydrophilic and/or lipophilic substances.

Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules

The invention relates to nanocapsules with a liquid lipidic core and a solid lipidic shell, the lipidic core being loaded with at least one water-soluble or water-dispersible ingredient, said ingredient being present in the form of a reverse micellar system.

Nanocapsules with a liquid lipid core charged with water-soluble or water-dispersible active agents

A process for preparing nanocapsules with a liquid lipid core and a solid lipid shell, charged with at least one active agent. The process contains at least the steps of formulating a microemulsion by phase inversion of an emulsion, totally or partially forming from at least one active agent a second composition different than the microemulsion, placing the microemulsion in contact with the second composition under conditions suitable for interaction of the active agent with the microemulsion, and chill-hardening the microemulsion that has interacted with the active agent, to obtain the nanocapsules.

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Strasbourg, France

Nicolas Anton