University of Pittsburgh

Scienceplusplease, LLC

Nicolas Alexander Alba

Mingui Sun

Xinyan Cui

Prahlad Menon Gopalakrishna

Philip M Sauter

Alexander Kharlamov

Stephen Carter Jones

Samuel J Hund

Eric Singer

An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q' ratio of at least 5 as defined by the equation wherein Wis the dry weight of the hydrophilic polymer and Wis weight of water in the sample after absorption of the electrolyte fluid comprising water and an electrolyte salt. The surface contact element can consist essentially of the hydrophilic polymer swollen by the electrolyte fluid. Another electrode system includes a contact element including a crosslinked hydrophilic polymer matrix. The contact element has a Q&#x2032; ratio of at least 5 as defined by the equation The contact elements can also have a Q&#x2032; ratio of at least 6, at least 7, at least 10 or even at least 11.

Electrode systems, devices and methods

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

Non-invasive systems and methods to detect cortical spreading depression for the detection and assessment of brain injury and concussion

An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q' ratio of at least 5 as defined by the equation wherein Wis the dry weight of the hydrophilic polymer and Wis weight of water in the sample after absorption of the electrolyte fluid comprising water and an electrolyte salt. The surface contact element can consist essentially of the hydrophilic polymer swollen by the electrolyte fluid. Another electrode system includes a contact element including a crosslinked hydrophilic polymer matrix. The contact element has a Q&#x2032; ratio of at least 5 as defined by the equation  The contact elements can also have a Q&#x2032; ratio of at least 6, at least 7, at least 10 or even at least 11.

Growing community of inventors

Pittsburgh, PA, United States of America

Nicolas Alexander Alba