Gist-brocades N.v.

Dsm N.v.

Nicolaas Cornelis Barendse

Jacobus Stark

Arthur F Marx

Hong Sheng Tan

Ferdinand Theodorus Van Rijn

Willem J Van Zoest

Jacobus N Batist

The present invention provides a method of preparing an improved antifungal composition containing an antifungal compound of the polyene type such as natamycin wherein the antifungal compound is incorporated into the composition in a form which shows an enhanced activity, e.g. in the form of a solution and/or being in a modified polymorphic form.

Antifungal composition

N-(sulfonylmethyl)formamides are obtained by reacting a sulfinic acid, formaldehyde and formamide in the presence of a second acid and a controlled amount of water. The formamides can be converted to the corresponding sulfonylmethylisocyanides.

Process for the preparation of N-(sulfonylmethyl) formamide compounds

9(11)-dehydroandrostanes and 9(11)-dehydropregnanes are prepared by dehydrating the corresponding 9-alpha-hydroxy steroid in the presence of a Lewis acid. The corresponding 8(9)-dehydro-isomer was not detectable. The resulting products are valuable intermediates in steroid synthesis especially in the preparation of corticosteroids.

Process for the preparation of 9(11)-dehydro steroids

Therapeutically useful 16-dehydro-androstane derivatives of the general formula: ##STR1## processes for their preparation and pharmaceutical compositions for the treatment of dermatological disorders, which contain as active ingredient at least one of the 16-dehydro-androstane derivatives as defined by the above formula.

Growing community of inventors

Den Hoorn, Netherlands

Nicolaas Cornelis Barendse