Duphar International Research Bv

Nicolaas Buizer

Chris G Kruse

Belal Shadid

Melle Van Der Laan

Gustaaf Jm Van Scharrenburg

Maria C Snoek

Klara M Schenk

Georges Langrand

The invention relates to a method for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer, characterized in that a substantially pure enantiomer of the general formula ##STR1## is prepared from a compound of the general formula ##STR2## wherein the variable are as defined as in claim 1. The method comprises the following successive reaction steps:

Process for the stereoselective preparation of a hetero-bicyclic alcohol

The invention relates to an enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer, characterized in that a substantially pure enantiomer of the general formula ##STR1## wherein X is O, S, NH, N--(C.sub.1 -C.sub.4)alkyl or CH.sub.2 ; Y.sub.1, Y.sub.2 and Y.sub.3 are each independently hydrogen or substituents selected from halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, nitro and cyano;

Enzymatic process for the stereoselective preparation of a

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Weesp, Netherlands

Nicolaas Buizer