Indena S.p.a.

Nicola Sardone

Andrea Gambini

Daniele Ciceri

Maurizio Ricotti

Pietro Allegrini

Bruno Gabetta

Federico Peterlongo

Stefano Luca Giaffreda

Alex Petrolati

Enrico Modena

The present invention provides novel crystalline forms of 4-[3-Chloro-4-(N'-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate, as well as methods for their preparation.

Crystal forms of lenvatinib

Disclosed are solid forms of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) selected from an amorphous form or a crystalline anhydrous form. Also disclosed are solid solvates of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) selected from an acetone solvate, a dimethylcarbonate solvate, an isopropyl ether solvate, an acetonitrile solvate, a toluene solvate, a mesitylene solvate, a nitromethane solvate, a dichloromethane/heptane solvate and an ethyl acetate solvate, for use as intermediates.

Solid forms of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) and method for preparing the same

The present invention relates to solid forms of 13-(N-Boc-&#x3b2;-isobutylserinyl)-14-&#x3b2; hydroxybaccatin III 1, 14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.

Solid forms of ortataxel

A crystalline from of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III.

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Milan, Italy

Nicola Sardone