Micromass UK Limited

Waters Technologies Ireland Limited

Nicola Lumley

David Douce

Arvind Rangan

Carl Chen

Veronica Lum

David S Douce

Nathaniel Martin

Pham Hoang Vu Ngo

Enchen Guo

Steven Rocha

David Jackson

An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an inlet for receiving at least the distal end of a capillary into the ionisation chamber in use; a desolvation heater including a heating element, for directing a stream of heated gas onto the distal end of the capillary in use; a corona discharge device arranged in the ionisation chamber; and a control system configured to operate the source in a selected one of: an analytical mode, in which the heating element is heated to a first temperature within a first temperature range, and in which a first current within a first current range is supplied to the corona discharge device; and a capillary priming mode, in which the heating element is heated to a second temperature within a second temperature range, and in which a second current within a second current range is supplied to the corona discharge device, wherein the lower limit of the second temperature range is higher than the lower limit of the first temperature range, and the second current range is higher than the first current range.

Atmospheric pressure ionisation source

A nozzle for directing heated gas onto the distal end of a capillary arrangeable adjacent the nozzle, the nozzle comprising: a housing defining a plenum for heated gas; and at outlet comprising at least one aperture fluidly connected to the plenum, the outlet configured to direct a curtain of the heated gas onto the distal end of a capillary in use, such that the curtain of heated gas is substantially aligned with the longitudinal axis of the capillary.

Atmospheric solids analysis source assembly

A holder for a capillary, comprising: a housing having a passage to receive a capillary; and a clamping mechanism configurable between: an engaged state in which the clamping mechanism is configured to retain a capillary receivable in the passage in use; and a disengaged state in which the clamping mechanism is configured to allow insertion/removal of a capillary in the passage in use; and a release mechanism operatively associated with the clamping mechanism and movable between a first position, in which the clamping mechanism is configured in said engaged state; and a second position, in which the clamping mechanism is configured in aid disengaged state, wherein the release mechanism is configured to bias the clamping mechanism towards the engaged state, wherein the passage in the housing comprises an end stop, configured to abut the end of a capillary inserted in the passage in use.

Holder for a capillary triggered to hold when a capillary is inserted

Exemplary embodiments provide methods, mediums, and systems for comparing a sample of interest to a library of known compounds to quickly determine how similar the sample is to the compounds in the library. Peaks of interest in the sample data are compared to corresponding peaks in the library compound data. These peaks may be represented as vectors, and an angle between the sample vector and the library vector may be used as a similarity metric. In some embodiments, a cosine similarity may be calculated for the vectors. If the similarity score for a given library compound/sample pair exceed a threshold, then the system determines that the library compound and the sample are similar and takes appropriate action. Various parameters associated with the comparison can be adjusted in order to improve the quality of the results and/or the efficiency of the process.

Methods, mediums, and systems for identifying samples of interest by vector comparison

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Wilmslow, United Kingdom

Nicola Lumley