Interleukin Genetics, Inc.

Ihc Health Services

Nicola Jane Camp

Gordon W Duff

Francesco Saverio Di Giovine

Angela Cox

Victor Abkevich

Donna Shattuck

Deanna L Russell

Chris Neff

Lisa Cannon-Albright

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and/or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations/alterations, which are useful for diagnosing the predisposition to depression.

Depression gene

Methods and kits for determining whether a subject has or is predisposed to developing a disease which is associated with IL-1 polymorphisms and assays for identifying therapeutics for treating and/or preventing the development of these diseases are provided.

Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype

Growing community of inventors

Salt Lake City, UT, United States of America

Nicola Jane Camp