Zach System

Wyeth

Nicola Catozzi

Massimo Verzini

Livius Cotarca

Giorgio Soriato

Johnny Foletto

Roberto Giovanetti

Massimiliano Forcato

Andrea Nicoli

Ivan Michieletto

Roberto Brescello

Paolo Andreella

Mauro Maffini

Paolo Fornasari

Franco Brazzarola

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.

Process for preparing Cinacalcet hydrochloride

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.HCl and its intermediate of formula (IX) 

Process for preparing cinacalcet

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb). 

Process for preparing Cinacalcet

The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.

Polymorphic Form D of bazedoxifene acetate and methods of preparing same

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Isola Vicentina, Italy

Nicola Catozzi