Farmitalia Carlo Erba S.r.l.

Pharmacia & Upjohn

Nicola Carfagna

Mario Varasi

Sergio Mantegani

Enzo Brambilla

Carla Caccia

Franco Heidempergher

Ruggero Fariello

Tiziano Bandiera

There are provided compounds of formula (I), wherein R,is a hydrogen, chlorine or bromine atom or a methyl, methylthio, hydroxy, cyano or carboxamido group; R,is C,-C,alkyl or an alkyl group; R,and R,are independently a hydrogen atom, a C,-C,alkyl group, a C,-C,alkenyl group, a C,-C,cycloalkyl C,-C,alkyl group, a phenyl-C,-C,alkenyl or phenyl group: which groups are optionally substituted by C,-C,alkyl, C,-C,alkoxy, triflouromethyl, hydroxy or amino group; or a group of formula (a), wherein R,is hydrogen atom or a C,-C,alkyl group and R,is a phenyl group, a substituted phenyl group as described above or a heterocyclic ring, R,is a hydrogen or bromine atom or an organic residue and R is H or an organic residue, or a pharmaceutically acceptable salt thereof. A process for their preparation and the pharmaceutical compositions comprising them are also provided.

Abeo-ergoline derivatives as 5HT1A ligands

Antineurodegenerative ergoline derivatives

The present invention provides compounds of the formula (I) ##STR1## wherein A, R.sub.1, R.sub.2 and R.sub.3 are defined as in the specification, or a pharmaceutically acceptable salt thereof. A process for their preparation and the pharmacetical compositions comprising them are also provided.

Serotoninergic ergoline derivatives

Derivatives of 1-phenyl-3-azabicycloalkylimidazolidin-2-ones are provided of general formula (I) ##STR1## in which inter alia R.sub.3 represents a group ##STR2## wherein n is an integer of 1 or 2 and R.sub.8 is hydrogen, C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by phenyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, formyl or C.sub.2 -C.sub.6 alkanoyl; and the pharmaceutically acceptable salts thereof, which are useful in the treatment of CNS disorders, gut motility disorders, emesis and migraine, as cognition activators, anti-drug addition agents and analgesic.

Derivatives of substituted imidazol-2-one and process for their

Derivatives of 1-phenyl-3-azabicycloalkylimidazolidin-2-ones are provided of general formula (1) ##STR1## in which inter alia R represents a group ##STR2## wherein n is an integer of 1 or 2 and R.sub.8 is hydrogen, C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by phenyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, formyl or C.sub.2 -C.sub.6 alkanoyl; and the pharmaceutically acceptable salts thereof. which are useful in the treatment of CNS disorders, gut motility disorders, emesis and migraine, as cognition activators, anti-drug addition agents and analgesic.

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Nerviano, Italy

Nicola Carfagna