Forty Seven, Inc.

Sanofi Pasteur Biologics, LLC

Sanofi Pasteur Inc.

Nicola Beltraminelli

Pierre Garrone

Harold Kleanthous

Klaus Heinrich Schwamborn

Stephen F Anderson

Jianxin Zhang

Natalie Anosova

Majid Mehtali

Mehdi Lahmar

Stéphanie Fallot

Marie Châlons-Cottavoz

Marie CHÂLONS-Cottavoz

Monoclonal antibodies, or antigen-binding fragments thereof, that bind to() toxin A or toxin B and methods of using the same to detect or treatinfections and/or-associated disease.

Antibodies against clostridium difficile toxins and methods of using the same

Humanized, mouse or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to human glycosylated and deglycosylated CD47 with an optimized Koff value, they disrupt the human CD47-SIRPα interaction, and find use in various therapeutic, preventive or diagnostic methods. The invention includes isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid and nucleotide sequences of the antibodies.

Humanized, mouse or chimeric anti-CD47 monoclonal antibodies

Humanized, mouse or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to human glycosylated and deglycosylated CD47 with an optimized Koff value, they disrupt the human CD47-SIRP&#x3b1; interaction, and find use in various therapeutic, preventive or diagnostic methods. The invention includes isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid and nucleotide sequences of the antibodies.

Antibodies againsttoxins and methods of using the same

Monoclonal antibodies or antigen-binding fragments thereof, that bind to() toxin A or toxin B and methods of using the same to detect or treatinfections and/or-associated disease.is a gram positive, anaerobic bacterium that causes gastrointestinal disease in humans. The bacteria are transmitted through feces and spread to food and other surfaces when people who are infected do not thoroughly wash their hands.

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Lyons, France

Nicola Beltraminelli