Colgate Palmolive Company

Universiteit Gent

Katholieke Universiteit Leuven

Janssen Pharmaceutica Nv

Nico Boon

Marc Quirynen

Wim Teughels

Hans Stettler

Willy Verstraete

Wim De Windt

Tom Van De Wiele

Hansruedi Stettler

Tom Defoirdt

Mariane Van Wambeke

Gitte Loozen

The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myo-inositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.

Prebiotic oral care methods using a saccharide

The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.

Prebiotic oral care compositions containing amino acids

The present invention provides an oral care composition comprising a carboxylic acid of the formula (I) wherein: Ris H, or is a substituted or unsubstituted alkyl group; and Ris H, OH, or NH; for use in: (a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; (b) selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria; or (c) maintaining and/or re-establishing a healthy oral microflora. 

Prebiotic oral care compositions containing carboxylic acids

The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myoinositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.

The disclosure relates to an oral care composition an effective amount of at least one C?1-4#191 (optionally hydroxylated) alkyl glycoside, e.g., &#x3b2;-methyl-D-galactoside, wherein the glycoside promotes the growth of beneficial endogenous bacteria and negatively affects the growth of endogenous pathogenic strains of bacteria. The disclosure also relates to methods of use, methods of screening, and methods of manufacture of said oral care compositions.

Prebiotic oral care compositions containing an alkyl glycoside

This invention relates to the use of hydroxybutyrate and poly hydroxybutyrate as components of animal feed or feed additives, as well as to compositions, feed additives and feed containing them. The inventors surprisingly found that hydroxybutyrate and poly-hydroxybutyrate, preferably 3-hydroxybutyrate and poly-3-hydroxybutyrate, have a great potential for use in animal feed for modulation of the gut flora. More precisely, it has been found that poly-3-hydroxybutyrate or a microbial strain capable for producing poly-3-hydroxybutyrate can be used as a potential growth promoter or gut flora modulator by releasing SCFA, preferably 3-hydroxy butyric acid, in the gut micro flora. Further, the inventors found that 3-hydroxybutyrate and poly-3-hydroxybutyrate have a great potential for suppressing or inhibiting pathogenic bacteria in the gastro intestinal tract, e.g. have a antimicrobial activity against strains ofand

Hydroxybutyrate and poly-hydroxybutyrate as components of animal feed or feed additives

Silver nanoparticles associated with 20 to 80% by weight of a biocomponent of the genus, said silver nanoparticles having a ratio of the average particle size to the specific surface area (BET) of from 0.015 to 0.15 nm/m/g; a method for producing silver nanoparticles, comprising the step of incubating bacteria of the genuswith an aqueous solution comprising at least 4 mM of a silver salt in the presence of ammonia and an alkali metal hydroxide until a biomass of bacteria containing Agsilver nanoparticles is formed; and optionally a further step of extracting said Agsilver nanoparticles from said biomass by means of concentrated alkali metal hydroxide or concentrated inorganic acid or enzymes; an anti-microbial composition comprising an effective amount of said silver nanoparticles; use of said silver nanoparticles for the manufacturing of an article or a composition with anti-microbial activity; a method for manufacturing an article or a composition with anti-microbial activity, comprising dispersing or impregnating said silver nanoparticles into said article or composition; and an article with anti-microbial property having said silver nanoparticles dispersed therein.

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Oosterzele, Belgium

Nico Boon