Janssen Alzheimer Immunotherapy

Telik, Inc.

Wyeth

Janssen Sciences Ireland Uc

Nicki Vasquez

Dale Bernard Schenk

Theodore A Yednock

Lawrence M Kauvar

John W Patterson

Hugo O Villar

Dorit Ron

Anna Voronova

Gene Napolitano

Ted Yednock

The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A&#x3b2; in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of A&#x3b2; and antibodies binding to the same.

Prevention and treatment of amyloidogenic disease

Compounds having immunomodulating activity are identified using a methodology which employs TER14687, TER10311 and/or TER17210 as standards. The effect candidate compounds have on PKC-theta interaction with cognate binding proteins is measured and compared with the standards. The interaction can be measured by a variety of techniques, including assessing translocation of said PKC-theta or fragment. Kits containing the TER14687, TER10311 and/or TER17210 standards are disclosed. TER14687, TER10311 and/or TER17210 are useful in modulating the immune system in a subject by reducing T-cell activity. TER14687, TER10311, TER17210 are used as leads to develop other compounds having immunomodulating activity.

Methods to identify immunomodulators using cognate interaction of

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San Francisco, CA, United States of America

Nicki Vasquez