University of Texas System

Baylor College of Medicine

Nick V Grishin

Beth Levine

Olivier Lichtarge

Angela D Wilkins

Sanae Shoji-Kawata

Lisa N Kinch

Joseph L Goldstein

Michael S Brown

Jing Yang

Beth C Levine

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties Rand R, respectively, wherein up to six of said peptide residues may be substituted, Rand Rdo not naturally flank the Beclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.

Autophagy-inducing peptide analogs

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 residues 269-279 immediately N- and C-terminally flanked by moieties Rand R, respectively, wherein up to six of said residues may be substituted, Rand Rdo not naturally flank the Belclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.

Ghrelin is acylated by ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a resultant decrease in acylation of the ghrelin by the acyltransferase.

Ghrelin o-acyltransferase (GOAT) biochemical assay

Growing community of inventors

Dallas, TX, United States of America

Nick V Grishin