Ortho-clinical Diagnostics, Inc

Johnson & Johnson Clinical Diagnostics, Inc.

Nicholas VanBrunt

Merrit Nyles Jacobs

James D Shaw

Russel H Marvin

Joseph John Dambra

Robert Anthony Burkovich

Randy Kristopher Bower

Gary A Graham

A method for measuring the amount of fluid contained in a reaction vessel in a clinical analyzer includes the steps of adding a first aliquot of fluid to the reaction vessel and measuring the quantity of fluid contained therein. A second aliquot of fluid is then added to the reaction vessel and the quantity of fluid contained therein is also measured. Measurement of the two fluid quantities can occur with or without removal of the first aliquot in between measurements. In obtaining the two quantity measurements and comparing them against a standard, the effects of well geometry can be minimized. Preferably, a delta or ratio measurement is obtained between the first and second liquid volume measurements which can be compared against a standard so as to normalize apparent volume losses or gains due to reaction well dimensional variation. This approach enhances the analytical capability to detect true fluid delivery errors.

Fluid measurements in a reaction vessel used in conjunction with a clinical analyzer

A centrifuge and method of operating it, wherein a patient sample tube is first spun while non-aligned with the centrifugal force to make use of the Boycott effect, and then while aligned with the centrifugal force to allow any gel present between the separated phases to properly seal. A latch is used to hold it in the non-aligned position until the latch is opened.

Centrifuge and phase separation

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Rochester, NY, United States of America

Nicholas VanBrunt