University of Washington

Case Western Reserve University

Nicholas P Reder

Anant Madabhushi

Cheng Lu

Adam K Glaser

Can Koyuncu

Jonathan T Liu

Jonathan Teng-Chieh Liu

Lawrence D True

Embodiments discussed herein facilitate determining a diagnosis and/or prognosis for prostate cancer based at least in part on three-dimensional (3D) pathomic feature(s). One example embodiment comprises a computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, comprising: accessing a three-dimensional (3D) optical image volume comprising a prostate gland of a patient; segmenting the prostate gland of the 3D optical image volume; extracting one or more features from the segmented prostate gland, wherein the one or more features comprise at least one 3D pathomic feature; and generating, via a model based at least on the one or more features, one or more of the following based at least on the extracted one or more features: a classification of the prostate gland as one of benign or malignant, a Gleason score associated with the prostate gland, or a prognosis for the patient.

Analysis of prostate glands using three-dimensional (3D) morphology features of prostate from 3D pathology images

Devices and techniques for a light sheet microscope device are generally described. In some examples, the light sheet microscope may comprise a motorized movable stage comprising an optically clear glass plate. In some further examples, the light sheet microscope may comprise an illumination objective and a collection objective disposed on a first side of the optically clear glass plate. In some further examples, the light sheet microscope may comprise a wavefront- and index-matching element disposed on the first side of the optically clear glass plate. An oil layer may be disposed between the optically clear glass plate and the wavefront- and index-matching element. The oil layer, the wavefront- and index-matching element and the glass plate may have matching refractive indexes.

Inverted light-sheet microscope

Growing community of inventors

Seattle, WA, United States of America

Nicholas P Reder