Newlink Genetics Corporation

Lankeanau Institute for Medical Research

Lankenau Institute for Medical Research

Nicholas N Vahanian

Firoz Jaipuri

Mario Mautino

Charles J Link

Gabriela Rossi

Won-Bin Young

Sanjeev Kumar

Jesse Waldo

Tanay Kesharwani

George C Prendergast

Charles J Link, Jr

Tatiana Seregina

William Malachowski

James N Higginbotham

Judith Lalonde

W Jay Ramsey

Bradley J Powers

Sachet A Shukla

Won Bin Young

The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce &#x3b1;Gal epitopes or &#x3b1;Gal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-&#x3b1;Gal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

Enhanced immunogenicity of tumor associated antigens by addition of alphagal epitopes

Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R, R, and Rare defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease. 

IDO inhibitors

Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R, R, and Rare defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease. 

The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce &#x3b1;Gal epi topes or &#x3b1;Gal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-&#x3b1;Gal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

Enhanced immunogenicity of tumor associated antigens by addition of &#x3b1;gal epitopes

Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes

The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly or indirectly involved in different tissue types, disease states, or other cellular differences desirable for diagnosis or for targets for drug therapy.

Methods and compositions for elucidating relative protein expression levels in cells

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Polk City, IA, United States of America

Nicholas N Vahanian