Dana-farber-cancer Institute Inc.

Pharma Mar, S.a.

Nicholas Mitsiades

Kenneth Carl Anderson

Constantine S Mitsiades

Teru Hideshima

Joseph R Bertino

Glynn Thomas Faircloth

Daniel J Medina

Joseph Negri

Douglas W McMillin

Daniel Medina

The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.

Methods and compositions for treating cancer using proteasome inhibitors

Herein is provided methods and compositions for treating cancer. In one embodiment, a method is provided for treating a patient suffering from cancer, the method comprising administering to the patient an effective amount of reversine, reversine analog or reversine containing agent. In another embodiment, compositions comprising reversine are provided. Such compositions may further comprise additional active agents and other additives. The compositions and methods provided herein are useful, for example, in the area of medicine.

Use of reversine and analogs for treatment of cancer

Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.

Aplidine for multiple myeloma treatment

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Roxbury, MA, United States of America

Nicholas Mitsiades