Flagship Pioneering Innovations Vi, LLC

Nicholas Mccartney Plugis

Avak Kahvejian

Morag Helen Stewart

Alexandra Sophie De Boer

Fabian Alexander Wolf

Umut Eser

Ellese Marie Carmona

Methods of associating a test compound with a compound property. One or more datasets including: for each of a plurality of cell lines and each of a plurality of compounds: for each respective exposure condition: a corresponding response signature for the respective compound in the respective cell line under the respective exposure condition is obtained. A correlation is determined for each unique combination of exposure conditions for a respective pair of compounds based on the corresponding response signature. A weight is determined for each respective pair of compounds based on the determined correlations. A plurality of compound clusters is formed, where each cluster represents compounds that satisfy one or more weight criteria with respect to a particular compound. A compound property of the test compound is determined from properties of one or more compounds in a one or more compound clusters that contain the test compound.

Systems and methods for associating compounds with properties using clique analysis of cell-based data

This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.

Compositions comprising circular polyribonucleotides and uses thereof

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Cambridge, MA, United States of America

Nicholas Mccartney Plugis