Flagship Pioneering Innovations Vi, LLC

Nicholas McCartney Plugis

Avak Kahvejian

Morag Helen Stewart

Sebastian Trousil

Erica Gabrielle Weinstein

Alexandra Sophie De Boer

Ki Young Paek

Catherine Cifuentes-Rojas

Fabian Alexander Wolf

Ragy Haddad

Umut Eser

Michael Raymond Retchin

Poorya Hosseini

A database processing system performs a first database access call accessing a first construct representing a differential component amount between a normal and different state. This identifies a plurality of components and, for each, a corresponding first association between (a) a change in amount of the respective component in a first plurality of first component datasets and a second plurality of second component datasets and (b) a change in state between the normal and different state. A second database access call accesses a second construct representing a measure of differential component amount between a native and exposed sample. The second construct identifies all or a portion of the plurality of components and, for each, a corresponding second association between a change of amount of the respective component between a third and fourth plurality of component datasets. The first associations and corresponding second associations determine whether the entity affects the transition.

Database processing system for determining whether an entity affects a transition

Systems and methods for associating a compound with physiological conditions are provided. A fingerprint of a compound chemical structure is obtained and inputted to a model that outputs one or more calculated activation scores. Each activation score represents a cellular constituent module in a set of modules, where each module includes a subset of cellular constituents and a first module in the set of modules is associated with the physiological condition. When the activation score for the first module satisfies a threshold criterion, the compound is identified as associated with the physiological condition. In some aspects, each activation score represents a perturbation signature associated with the physiological condition and the compound is identified when the activation score for a first perturbation signature satisfies a threshold criterion. Systems and methods for training a model that associates compounds with physiological conditions are also provided.

Systems and methods for associating compounds with physiological conditions using fingerprint analysis

Methods of associating a test compound with a compound property. One or more datasets including: for each of a plurality of cell lines and each of a plurality of compounds: for each respective exposure condition: a corresponding response signature for the respective compound in the respective cell line under the respective exposure condition is obtained. A correlation is determined for each unique combination of exposure conditions for a respective pair of compounds based on the corresponding response signature. A weight is determined for each respective pair of compounds based on the determined correlations. A plurality of compound clusters is formed, where each cluster represents compounds that satisfy one or more weight criteria with respect to a particular compound. A compound property of the test compound is determined from properties of one or more compounds in a one or more compound clusters that contain the test compound.

Systems and methods for associating compounds with properties using clique analysis of cell-based data

This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.

Compositions comprising circular polyribonucleotides and uses thereof

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Boston, MA, United States of America

Nicholas McCartney Plugis