Novartis Vaccines & Diagnostics, Gmbh

Novartis Ag

Novartis Vaccines and Diagnostics Srl

Other

Modernatx, Inc.

Irm LLC

Nicholas M Valiante

Derek T O'Hagan

James Clifford Sutton

Alex Cortez

Xiaoyue Zhang

Yongkai Li

Yefen Zou

Pranab Mishra

Feng Xu

Manmohan Singh

Weibo Wang

Jiong Lan

Keith Bruce Pfister

Allan S Wagman

Paul Andrew Barsanti

Tom Yao-Hsiang Wu

Eric Yi-Chun Huang

Amy J Weiner

Simon C Ng

Zhi-Jie Ni

Liana Marie Lagniton

Antonello Covacci

Nathan Brammeier

David Skibinski

Tom Yao Hsiang Wu

Sze-Wah Tse

Jared Iacovelli

Kristine McKinney

Jeffrey Ulmer

Claudio Donati

Anthony Diebes

Casey Philbin

The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.

Immunomodulatory therapeutic MRNA compositions encoding activating oncogene mutation peptides

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: Xis N; Xis N Or CR; Xis &#x2014;CR&#x2550;CR. 

Compounds and compositions as TLR activity modulators

A combination of CpG oligonucleotides and polymer microparticles is an extremely effective adjuvant for Neisserial antigens. The invention therefore provides a composition comprising: (a) a Neisserial antigen; (b) a CpG oligonucleotide; and (c) a biodegradable polymer microparticle.

Adjuvanted meningococcus compositions

The invention provides immunostimulatory compositions and methods of administration thereof. Also provided are methods of administering a tryptanthrin compound in an effective amount to enhance the immune response of a subject to an antigen. Also provided are methods of administering an effective amount of a tryptanthrin to stimulate the immune response in a subject for the treatment of cancer. Further provided are methods of administering a tryptanthrin compounds as an immunotherapeutic in the treatment of infectious diseases.

Use of tryptanthrin compounds for immune potentiation

The invention provides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an) other agent(s). 

Imidazoquinoxaline compounds as immunomodulators

A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.

Pamps, pathogen associated molecular patterns

The invention provides novel compositions comprising Imidazopyridine compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an)other agent(s).

Immunopotentiating compounds

A dimeric protein comprising a first fusion protein and a second fusion protein, wherein the first fusion protein comprises a targeting domain, a leucine zipper domain, and an antigen; and wherein the second fusion protein comprises a targeting domain, a leucine zipper domain, and optionally an antigen. Nucleic acid vectors encoding proteins of the invention are provided, particularly for use in nucleic acid vaccination.

Dimeric proteins for immunization

The invention provides immunostimulatory compositions comprising a small molecule immuno-poteniator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma.

Use of small molecule compounds for immunopotentiation

Adjuvant compositions comprising type 1 interferon inducers, such as double-stranded RNA, in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.

Adjuvant compositions

Nucleic acid vectors for immunization

The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.

Thiosemicarbazones as anti-virals and immunopotentiators

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Fremont, CA, United States of America

Nicholas M Valiante