University of California

Nicholas J Wang

Joe W Gray

William J Gibb

Paul T Spellman

Laura M Heiser

Anguraj Sadanandam

Wen-lin Kuo

Herein is described the use of a collection of 50 breast cancer cell lines to match responses to 77 conventional and experimental therapeutic agents with transcriptional, proteomic and genomic subtypes found in primary tumors. Almost all compounds produced strong differential responses across the cell lines produced responses that were associated with transcriptional and proteomic subtypes and produced responses that were associated with recurrent genome copy number abnormalities. These associations can now be incorporated into clinical trials that test subtype markers and clinical responses simultaneously.

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Porland, OR, United States of America

Nicholas J Wang