Columbia University

Inrad, Inc.

Alpine Kinetics, Inc.

Nicholas J Turro

Jeffrey T Koberstein

Denong Wang

Gregory T Carroll

Jingyue Ju

Dae Hyun Kim

Qinglin Meng

Lanrong Bi

Xiaopeng Bai

Jeremiah Johnson

James R Fehlner

Jeffrey Lancaster

Ellane J Park

This invention provides a process for making 3'-O-allyl-dGTP-PC-Biodopy-FL-510, 3&#x2032;-O-allyl-dATP-PC-ROX, 3&#x2032;-O-allyl-dCTP-PC-Bodipy-650 and 3&#x2032;-O-allyl-dUTP-PC-R6G, and related methods.

Synthesis of four-color 3'-O-allyl modified photocleavable fluorescent nucleotides and related methods

Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.

Photochemical methods and photoactive compounds for modifying surfaces

Methods for functionalizing a surface of a substrate with nanoparticles are described. In certain embodiments, the method can include attaching a plurality of photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each photoactive linker comprises a binding group that attaches to the nanoparticles and a photoactive group; depositing the photoactive nanoparticles to the surface of the substrate, wherein the surface of the substrate comprises reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive nanoparticles with radiation to react the photoactive group with the reactive group and to functionalize the surface of the substrate with nanoparticles. In certain embodiments, the method can include attaching a plurality of photoactive linker linkers to a surface of a substrate to obtain a photoactive surface, wherein each photoactive linker comprises a photoactive group and a binding group that attaches to the surface of the substrate; depositing nanoparticles to the photoactive surface, wherein the nanoparticles comprise reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive surface with radiation to react the photoactive group with the reactive group to functionalize the surface of the substrate with nanoparticles.

Modification of surfaces with nanoparticles

The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.

Macromonomers for preparation of degradable polymers and model networks

In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.

Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials

The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a high-throughput strategy to facilitate the identification and immunological characterization of pathogen-specific carbohydrates, including those of. The invention can be used to determine the presence of a pathogen and whether a subject has been exposed to a pathogen, such as by screening for pathogen-specific antibodies.

Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies

The present invention relates to functionalizing a surface of an organic material. For example, surfaces of materials having C&#x2014;H bonds, such as polymers having C&#x2014;H bonds, can be functionalized. In certain embodiments, a heterobifunctional molecule having a photoactive anchor, a spacer, and a terminal functional group is applied to the surface of an organic material that contains one or more C&#x2014;H bonds. The heterobifunctional molecule can be bound to any surface having C&#x2014;H bonds as the photoactive anchor can react with C&#x2014;H bonds upon irradiation. The terminal functional group has a 'click' functionality which can be utilized to functionalize the surface of the organic material with any desired functionalizing moiety having the orthogonal click functionality.

Functionalization of organic surfaces

The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization CLICK chemistry and a tetrafunctional initiator having terminal halogen groups to form the desired product.

Method of preparing a star polymer macromonomer

Synthesis of four color 3'O-allyl, modified photocleavable fluorescent nucleotides and related methods

A terminally chlorinated normal alkane hydrocarbon is produced at high terminal selectivity, by adsorbing a normal alkane into a select zeolite and chlorinating the adsorbed alkane in the zeolite. The zeolite may be of a type having internal channels of diameter slightly larger than that of the alkane, and substantially no internal chambers, and may be selected from the pentasil family of zeolites. The chlorination reaction may be conducted under heating to enhance terminal selectivity even further, in many cases to levels approaching 100%.

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Tenafly, NJ, United States of America

Nicholas J Turro