University of California

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America

The Government of the United States of America

The United States of America As Represented by Nih

Nicholas J P Ryba

Charles S Zuker

Mark A Hoon

Jayaram Chandrashekar

Yifeng Zhang

Gregory A Nelson

Greg Nelson

Grace Q Zhao

Isolde Erlenbach

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1

The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.

Mammalian sweet taste receptors

The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian T1R3 sweet taste receptors

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian sweet and amino acid heterodimeric taste receptors

Mammalian sweet taste receptors t1r3

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Bethesda, MD, United States of America

Nicholas J P Ryba