Allergan, Inc.

Allergan Industrie, Sas

Spineovations, Inc.

Poragen LLC

Sprezzatura Innovations, LLC

Nicholas J Manesis

Xiaojie Yu

Futian Liu

Athene Wan Chie Chan

Gabriel N Njikang

Alexei Goraltchouk

Jacob Pollock

David J Schuessler

Dimitrios Stroumpoulis

Sumit Paliwal

Stuart W Young

Dustin Leslie

Nikhil S Trilokekar

Kaustubh S Chitre

Jessamine P Winer-Jones

Hengli Liu

Athene W Chan

Neville Alleyne

Elizabeta Pavlovic

Monica A Serban

Dylan B Hollrigel

Athene Wan Chan

Dennis E Van Epps

Jordan M Thompson

Kevin Ma

Dimitri Stroumpoulis

Miram M Abiad

Nevile Alleyne

Jessamine P Winer

Jacob F Pollock

Xiao Jie Yu

Dustin B Leslie

Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Hyaluronic acid-collagen matrices for dermal filling and volumizing applications

Methods and materials used for production of constructs having a porous open or semi-open celled structure. Constructs may include a porous matrix as a base and a biocompatible conformal coating thereon.

Biocompatible porous materials and methods of manufacture and use

A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

Method of treating spinal disk

The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Porogen compositions, methods of making and uses

The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

Dermal filler compositions

Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.

Dermal filler compositions including antioxidants

The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

Dermal filler compositions for fine line treatment

A laminate useful as a component of a medical implant, for example, useful as a component of an inflatable tissue expander. The laminate includes a base layer, an intermediate layer, and a top layer. When used as a component of a tissue expander, the laminate enables an internal chamber pressure of about 2.5 psi with an expander exterior compressive force of about 40 lbs.

Inflatable prostheses and methods of making same

Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

Cross linked silk-hyaluronic acid composition

Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Porous materials, methods of making and uses

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Summerland, CA, United States of America

Nicholas J Manesis