Unl Holdings LLC

Unitract Syringe Pty Ltd

Amgen Inc.

Rex Medical, L.p.

Nicholas J Ciccarelli

Ian B Hanson

Paul F Bente, Iv

Ryan Michael Agard

Sean M O'connor

Matthew J Clemente

Kevin Lee Bokelman

John Christian Love

Kun-Chi Wu

Sheldon B Moberg

Scott Robert Gibson

Daniel Davenport

Marc-Alan Levine

Margaux Frances Boyaval

John D Leedle

Daniel Shawn Codd

Rajan Ramaswamy

Scott Beaver

Mark A Destefano

Gautam N Shetty

Basel Hasan Taha

Michael Leedle

Christopher Edward Hatch

Robert Decker

Conall Joseph Dempsey

John Burke

Paul F Bente

Paul F Bente Iv

Sean M O`CONNOR

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Drug delivery device, method of manufacture, and method of use

A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Drive mechanism for drug delivery pumps with integrated status indication

Drug delivery pump

A fluid pathway assembly includes a needle insertion mechanism, a fluid conduit, and a fluid pathway connection. The fluid pathway assembly may further include a drug container to hold a drug fluid prior to initiation of the injection. The assembly may include a carrier disposed along at least a portion of the fluid pathway assembly, and/or a drug container. The fill-finish cartridge functions to retain the components of the fluid pathway assembly in a sterile condition, while allowing for easy integration of the fluid pathway assembly and the drug container into a standard fill-finish process. Methods of constructing a cartridge, filling a drug container included in a cartridge, and incorporating the same into a drug delivery device are disclosed.

Fill-finish cartridges for sterile fluid pathway assemblies and drug delivery devices incorporating fill-finish cartridges

A fluid pathway connection includes a piercing member, a connection hub, and a sliding pierceable seal, wherein the sliding pierceable seal is configured to move from a first position, where the piercing member is initially retained within a sterile cavity between the connection hub and the sliding pierceable seal, to a second position, where the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. The fluid pathway connection may further be configured to move to a third position where one or more interconnects and/or one or more corresponding contacts are permitted to transmit a signal to the user. Such fluid pathway connections may be integrated into a drug container having a barrel and a plunger seal. A drug delivery pump includes such integrated fluid pathway connections and drug containers.

Integrated sliding seal fluid pathway connection and drug containers for drug delivery pumps

A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

An assembly insertable into a lumen of a patient including a motor housing having a motor contained therein, a motor shaft extending from the motor, a first coupler positioned at the motor shaft having a first magnet positioned therein adjacent a distal end, a rotational wire, and a second coupler positioned at a proximal portion of the thrombectomy wire. The second coupler has a second magnet positioned therein adjacent a proximal end. The second coupler is engageable with the first coupler to operably connect the rotational wire to the motor shaft, the first and second magnets providing an attractive force between the first and second couplers to maintain a connection of the first and second couplers so rotation of the first coupler rotates the second coupler.

Rotational thrombectomy wire

An assembly for breaking up vascular thrombus or other obstructive material including a motor housing having a motor, a motor shaft extending from the motor, a first housing positioned at a distal end of the motor shaft, a rotational thrombectomy wire and a second housing positioned at a proximal end of the wire. The first housing has a first magnet positioned therein and recessed from the distal edge of the first housing which has a first plurality of teeth. The second housing has a second magnet positioned therein and recessed from a proximal edge of the second housing which has a second plurality of teeth intermeshing with the first plurality of teeth when the wire is coupled to the motor shaft. The first and second plurality of teeth slip when a torque of the motor shaft exceeds a predetermined value.

Rotational thrombectomy wire coupler

Growing community of inventors

Philadelphia, PA, United States of America

Nicholas J Ciccarelli